- Outcomes of a Delirium Prevention Program in Older Persons After Elective Surgery: A Stepped-Wedge Cluster Randomized Clinical Trial.
Deeken F, Sánchez A, Rapp MA, Denkinger M, Brefka S, Spank J, Bruns C, von Arnim CAF, Küster OC, Conzelmann LO, Metz BR, Maurer C, Skrobik Y, Forkavets O, Eschweiler GW, Thomas C; PAWEL Study Group.
JAMA Surg. 2022 Feb 1;157(2):e216370. doi: 10.1001/jamasurg.2021.6370. Epub 2022 Feb 9. - [75/f with cognitive impairment and dysgeusia, presentation 3 months after delirium : Preparation for the medical specialist examination: part 78].
Zieschang T, von Arnim C.
Internist (Berl). 2021 Nov;62(Suppl 5):513-518. doi: 10.1007/s00108-021-01139-1. Epub 2021 Sep 22. - Comparison of CSF and serum neurofilament light and heavy chain as differential diagnostic biomarkers for ALS.
Halbgebauer S, Steinacker P, Verde F, Weishaupt J, Oeckl P, von Arnim C, Dorst J, Feneberg E, Mayer B, Rosenbohm A, Silani V, Ludolph AC, Otto M.
J Neurol Neurosurg Psychiatry. 2022 Jan;93(1):68-74. doi: 10.1136/jnnp-2021-327129. Epub 2021 Aug 20. - Perimenopause and Postmenopause – Diagnosis and Interventions. Guideline of the DGGG and OEGGG (S3-Level, AWMF Registry Number 015-062, September 2020).
Inwald EC, Albring C, Baum E, Beckermann M, Bühling KJ, Emons G, Gudermann T, Hadji P, Imthurn B, Kiesel L, Klemperer D, Klose P, König K, Krüger S, Langhorst J, Leitzmann M, Ludolph A, Lüftner D, Müller D, Neulen J, Nothacker M; Eckhard Petri †, Prautzsch H, Regitz-Zagrosek V, Schaudig K, Schütz F, Schwenkhagen A, Strowitzki T, Stute P, Taute BM, Tempfer C, Arnim CV, Wildt L, Windler E, Ortmann O.
Geburtshilfe Frauenheilkd. 2021 Jun;81(6):612-636. doi: 10.1055/a-1361-1948. Epub 2021 Jun 2. - Protein Binding Partners of Dysregulated miRNAs in Parkinson’s Disease Serum.
Ruf WP, Freischmidt A, Grozdanov V, Roth V, Brockmann SJ, Mollenhauer B, Martin D, Haslinger B, Fundel-Clemens K, Otto M, Arnim CV, Holzmann K, Ludolph AC, Weishaupt JH, Danzer KM. - [Memory clinics in Germany-structural requirements and areas of responsibility].
Hausner L, Frölich L, von Arnim CAF, Bohlken J, Dodel R, Otto M, Rapp M, Schulz J, Supprian T, Wollmer MA, Jessen F;
Deutsches Netzwerk Gedächtnisambulanzen. Nervenarzt. 2021 Jul;92(7):708-715. doi: 10.1007/s00115-020-01007-7. Epub 2020 Oct 6. - Comparison of MRI-based and PET-based image pre-processing for quantification of 11C-PBB3 uptake in human brain.
Yousefzadeh-Nowshahr E, Winter G, Bohn P, Kneer K, von Arnim CAF, Otto M, Solbach C, Anderl-Straub S, Polivka D, Fissler P, Prasad V, Kletting P, Riepe MW, Higuchi M, Ludolph A, Beer AJ, Glatting G.
Z Med Phys. 2021 Feb;31(1):37-47. doi: 10.1016/j.zemedi.2020.12.002. Epub 2021 Jan 14. - Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation.
Aragão Gomes L, Uytterhoeven V, Lopez-Sanmartin D, Tomé SO, Tousseyn T, Vandenberghe R, Vandenbulcke M, von Arnim CAF, Verstreken P, Thal DR.
Acta Neuropathol. 2021 Feb;141(2):173-192. doi: 10.1007/s00401-020-02251-6. Epub 2021 Jan 11. - [B vitamins in geriatrics – what to determine, what to replace?].
Djukic M, von Arnim CAF.
Dtsch Med Wochenschr. 2021 Feb;146(3):152-156. doi: 10.1055/a-1210-5030. Epub 2021 Jan 29. PMID: 33513647 German. - Sequence of proteome profiles in preclinical and symptomatic Alzheimer’s disease.
Li X, Tsolis KC, Koper MJ, Ronisz A, Ospitalieri S, von Arnim CAF, Vandenberghe R, Tousseyn T, Scheuerle A, Economou A, Carpentier S, Otto M, Thal DR.
Alzheimers Dement. 2021 Jun;17(6):946-958. doi: 10.1002/alz.12345. Epub 2021 Apr 19. - Different Inflammatory Signatures in Alzheimer’s Disease and Frontotemporal Dementia Cerebrospinal Fluid.
Boström G, Freyhult E, Virhammar J, Alcolea D, Tumani H, Otto M, Brundin RM, Kilander L, Löwenmark M, Giedraitis V, Lleó A, von Arnim CAF, Kultima K, Ingelsson M.
J Alzheimers Dis. 2021;81(2):629-640. doi: 10.3233/JAD-201565. - NADH Fluorescence Lifetime Imaging Microscopy Reveals Selective Mitochondrial Dysfunction in Neurons Overexpressing Alzheimer’s Disease-Related Proteins.
Niederschweiberer MA, Schaefer PM, Singh LN, Lausser L, Bhosale D, Hesse R, Calzia E, Kestler HA, Rueck A, Wallace DC, von Einem B, von Arnim CAF.
Front Mol Biosci. 2021 Jun 14;8:671274. doi: 10.3389/fmolb.2021.671274. eCollection 2021 - [B vitamins in geriatrics – what to determine, what to replace?].
Djukic M, von Arnim CAF.
Dtsch Med Wochenschr. 2021 Feb;146(3):e56. doi: 10.1055/a-1512-4827. Epub 2021 May 28. - Presurgical Screening Improves Risk Prediction for Delirium in Elective Surgery of Older Patients: The PAWEL RISK Study.
Eschweiler GW, Czornik M, Herrmann ML, Knauer YP, Forkavets O, von Arnim CAF, Denkinger M, Küster O, Conzelmann L, Metz BR, Maurer C, Kentischer F, Deeken F, Sánchez A, Wagner S, Mennig E, Thomas C, Rapp MA.
Front Aging Neurosci. 2021 Jul 27;13:679933. doi: 10.3389/fnagi.2021.679933. eCollection 2021. - Efficacy and safety of pharmacotherapy for Alzheimer’s disease and for behavioural and psychological symptoms of dementia in older patients with moderate and severe functional impairments: a systematic review of controlled trials.
Seibert M, Mühlbauer V, Holbrook J, Voigt-Radloff S, Brefka S, Dallmeier D, Denkinger M, Schönfeldt-Lecuona C, Klöppel S, von Arnim CAF.
Alzheimers Res Ther. 2021 Jul 16;13(1):131. doi: 10.1186/s13195-021-00867-8. - No Evidence That Cognitive and Physical Activities Are Related to Changes in EEG Markers of Cognition in Older Adults at Risk of Dementia.
Laptinskaya D, Küster OC, Fissler P, Thurm F, Von Arnim CAF, Kolassa IT.
Front Aging Neurosci. 2021 Mar 19;13:610839. doi: 10.3389/fnagi.2021.610839. eCollection 2021. - Analysis of Frailty in Geriatric Patients as a Prognostic Factor in Endovascular Treated Patients with Large Vessel Occlusion Strokes.
Schnieder M, Bähr M, Kirsch M, Maier I, Behme D, Riedel CH, Psychogios MN, Brehm A, Liman J, von Arnim CAF.
J Clin Med. 2021 May 18;10(10):2171. doi: 10.3390/jcm10102171.
Bupropion for the Treatment of Apathy in Alzheimer Disease: A Randomized Clinical Trial.
Maier F, Spottke A, Bach JP, Bartels C, Buerger K, Dodel R, Fellgiebel A, Fliessbach K, Frölich L, Hausner L, Hellmich M, Klöppel S, Klostermann A, Kornhuber J, Laske C, Peters O, Priller J, Richter-Schmidinger T, Schneider A, Shah-Hosseini K, Teipel S, von Arnim CAF, Wiltfang J, Jessen F. JAMA Netw Open. 2020 May 1;3(5):e206027. doi: 10.1001/jamanetworkopen.2020.6027.
- Neurogeriatrics-a vision for improved care and research for geriatric patients with predominating neurological disabilities.
Jacobs AH, Emmert K, Baron R, Bartsch T, Bauer J, Becker C, Berg D, Bergmann P, Boetzel K, Bollheimer C, Deuschl G, Djukic M, Drey M, Durwen H, Ebersbach G, Elshehabi M, Geritz J, Gisinger C, Guennewig T, Hauptmann B, Heppner HJ, Hobert MA, Hofmann W, Huellemann P, Jahn K, Klucken J, Kurth R, Lindner R, Lingor P, Lukas A, Maetzold S, Mokrusch T, Mollenhauer B, Nau R, Plate A, Polidori MC, Prell T, Schellinger P, Spira D, Stephani U, Studt S, Trenkwalder C, Unger HL, Urban P, von Arnim CAF, Warnecke T, Weiss M, Wiedemann A, Wirth R, Witt K, Dodel R, Maetzler W. Z Gerontol Geriatr. 2020 Jul;53(4):340-346. doi: 10.1007/s00391-020-01734-1. Epub 2020 May 19.
- Targeted Mass Spectrometry Suggests Beta-Synuclein as Synaptic Blood Marker in Alzheimer’s Disease.
Oeckl P, Halbgebauer S, Anderl-Straub S, von Arnim CAF, Diehl-Schmid J, Froelich L, Grimmer T, Hausner L, Denk J, Jahn H, Steinacker P, Weishaupt JH, Ludolph AC, Otto M.
J Proteome Res. 2020 Mar 6;19(3):1310-1318. doi: 10.1021/acs.jproteome.9b00824. Epub 2020 Feb 26.
- Distinct molecular patterns of TDP-43 pathology in Alzheimer’s disease: relationship with clinical phenotypes.
Tomé SO, Vandenberghe R, Ospitalieri S, Van Schoor E, Tousseyn T, Otto M, von Arnim CAF, Thal DR.
Acta Neuropathol Commun. 2020 Apr 29;8(1):61. doi: 10.1186/s40478-020-00934-5.
- Global EEG coherence as a marker for cognition in older adults at risk for dementia.
Laptinskaya D, Fissler P, Küster OC, Wischniowski J, Thurm F, Elbert T, von Arnim CAF, Kolassa IT.
Psychophysiology. 2020 Apr;57(4):e13515. doi: 10.1111/psyp.13515. Epub 2019 Dec 16.
- Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease.
Koper MJ, Van Schoor E, Ospitalieri S, Vandenberghe R, Vandenbulcke M, von Arnim CAF, Tousseyn T, Balusu S, De Strooper B, Thal DR. Acta Neuropathol. 2020 Mar;139(3):463-484. doi: 10.1007/s00401-019-02103-y. Epub 2019 Dec 4.
- Correction to: Different aspects of Alzheimer’s disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia.
Thal DR, Ronisz A, Tousseyn T, Upadhaya AR, Balakrishnan K, Vandenberghe R, Vandenbulcke M, von Arnim CAF, Otto M, Beach TG, Lilja J, Heurling K, Chakrabarty A, Ismail A, Buckley C, Smith APL, Kumar S, Farrar G, Walter J.
Acta Neuropathol Commun. 2020 Aug 3;8(1):121. doi: 10.1186/s40478-020-01005-5.
- Diagnosis and treatment of cognitive impairment.
von Arnim CAF, Bartsch T, Jacobs AH, Holbrook J, Bergmann P, Zieschang T, Polidori MC, Dodel R.
Z Gerontol Geriatr. 2019 Jul;52(4):309-315. doi: 10.1007/s00391-019-01560-0. Epub 2019 Jun 3.
- Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer’s Disease and Correlates with Cognitive Impairment.
Oeckl P, Halbgebauer S, Anderl-Straub S, Steinacker P, Huss AM, Neugebauer H, von Arnim CAF, Diehl-Schmid J, Grimmer T, Kornhuber J, Lewczuk P, Danek A; Consortium for Frontotemporal Lobar Degeneration German, Ludolph AC, Otto M.
J Alzheimers Dis. 2019;67(2):481-488. doi: 10.3233/JAD-180325.
- Patient safety, cost-effectiveness, and quality of life: reduction of delirium risk and postoperative cognitive dysfunction after elective procedures in older adults-study protocol for a stepped-wedge cluster randomized trial (PAWEL Study).
Sánchez A, Thomas C, Deeken F, Wagner S, Klöppel S, Kentischer F, von Arnim CAF, Denkinger M, Conzelmann LO, Biermann-Stallwitz J, Joos S, Sturm H, Metz B, Auer R, Skrobik Y, Eschweiler GW, Rapp MA; PAWEL Study group.
Trials. 2019 Jan 21;20(1):71. doi: 10.1186/s13063-018-3148-8.
- Different aspects of Alzheimer’s disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia.
Thal DR, Ronisz A, Tousseyn T, Rijal Upadhaya A, Balakrishnan K, Vandenberghe R, Vandenbulcke M, von Arnim CAF, Otto M, Beach TG, Lilja J, Heurling K, Chakrabarty A, Ismail A, Buckley C, Smith APL, Kumar S, Farrar G, Walter J.
Acta Neuropathol Commun. 2019 Nov 14;7(1):178. doi: 10.1186/s40478-019-0837-9.
- NADH Autofluorescence-A Marker on its Way to Boost Bioenergetic Research.
Schaefer PM, Kalinina S, Rueck A, von Arnim CAF, von Einem B.
Cytometry A. 2019 Jan;95(1):34-46. doi: 10.1002/cyto.a.23597. Epub 2018 Sep 13.
- Comprehensive microRNA expression profiling in cerebrospinal fluid distinguishes between neurological disease classes.
Grasedieck S, Mulaw M, Sperb N, Wessinger K, Rouhi A, Bommer M, Bromberg JEC, Otto M, Tumani H, von Arnim CAF, Mertens D, Kuchenbauer F.
Neuropathol Appl Neurobiol. 2019 Apr;45(3):318-323. doi: 10.1111/nan.12491. Epub 2018 May 21.
- Serum Insulin and Cognitive Performance in Older Adults: A Longitudinal Study.
Hooshmand B, Rusanen M, Ngandu T, Leiviskä J, Sindi S, von Arnim CAF, Falkai P, Soininen H, Tuomilehto J, Kivipelto M.
Am J Med. 2019 Mar;132(3):367-373. doi: 10.1016/j.amjmed.2018.11.013. Epub 2018 Nov 29.
- Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis.
Verde F, Steinacker P, Weishaupt JH, Kassubek J, Oeckl P, Halbgebauer S, Tumani H, von Arnim CAF, Dorst J, Feneberg E, Mayer B, Müller HP, Gorges M, Rosenbohm A, Volk AE, Silani V, Ludolph AC, Otto M.
J Neurol Neurosurg Psychiatry. 2019 Feb;90(2):157-164. doi: 10.1136/jnnp-2018-318704. Epub 2018 Oct 11.
- Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein.
Gomes LA, Hipp SA, Rijal Upadhaya A, Balakrishnan K, Ospitalieri S, Koper MJ, Largo-Barrientos P, Uytterhoeven V, Reichwald J, Rabe S, Vandenberghe R, von Arnim CAF, Tousseyn T, Feederle R, Giudici C, Willem M, Staufenbiel M, Thal DR.
Acta Neuropathol. 2019 Dec;138(6):913-941. doi: 10.1007/s00401-019-02053-5. Epub 2019 Aug 14.
- The role of PTB domain containing adaptor proteins on PICALM-mediated APP endocytosis and localization.
Merthan L, Haller A, Thal DR, von Einem B, von Arnim CAF.
Biochem J. 2019 Jul 31;476(14):2093-2109. doi: 10.1042/BCJ20180840.
- Association of Methionine to Homocysteine Status With Brain Magnetic Resonance Imaging Measures and Risk of Dementia.
Hooshmand B, Refsum H, Smith AD, Kalpouzos G, Mangialasche F, von Arnim CAF, Kåreholt I, Kivipelto M, Fratiglioni L.
JAMA Psychiatry. 2019 Nov 1;76(11):1198-1205. doi: 10.1001/jamapsychiatry.2019.1694.
- A Proposal for the Retrospective Identification and Categorization of Older People With Functional Impairments in Scientific Studies-Recommendations of the Medication and Quality of Life in Frail Older Persons (MedQoL) Research Group.
Brefka S, Dallmeier D, Mühlbauer V, von Arnim CAF, Bollig C, Onder G, Petrovic M, Schönfeldt-Lecuona C, Seibert M, Torbahn G, Voigt-Radloff S, Haefeli WE, Bauer JM, Denkinger MD; Medication and Quality of Life Research Group.
J Am Med Dir Assoc. 2019 Feb;20(2):138-146. doi: 10.1016/j.jamda.2018.11.008. Epub 2019 Jan 9.
- Elecsys® Total-Tau and Phospho-Tau (181P) CSF assays: Analytical performance of the novel, fully automated immunoassays for quantification of tau proteins in human cerebrospinal fluid.
Lifke V, Kollmorgen G, Manuilova E, Oelschlaegel T, Hillringhaus L, Widmann M, von Arnim CAF, Otto M, Christenson RH, Powers JL, Shaw LM, Hansson O, Doecke JD, Li QX, Teunissen C, Tumani H, Blennow K.
Clin Biochem. 2019 Oct;72:30-38. doi: 10.1016/j.clinbiochem.2019.05.005. Epub 2019 May 23.
- Modified amyloid variants in pathological subgroups of β-amyloidosis.
Gerth J, Kumar S, Rijal Upadhaya A, Ghebremedhin E, von Arnim CAF, Thal DR, Walter J.
Ann Clin Transl Neurol. 2018 Jun 6;5(7):815-831. doi: 10.1002/acn3.577. eCollection 2018 Jul.
- Serum neurofilament light chain in behavioral variant frontotemporal dementia.
Steinacker P, Anderl-Straub S, Diehl-Schmid J, Semler E, Uttner I, von Arnim CAF, Barthel H, Danek A, Fassbender K, Fliessbach K, Foerstl H, Grimmer T, Huppertz HJ, Jahn H, Kassubek J, Kornhuber J, Landwehrmeyer B, Lauer M, Maler JM, Mayer B, Oeckl P, Prudlo J, Schneider A, Volk AE, Wiltfang J, Schroeter ML, Ludolph AC, Otto M; FTLDc study group.
Neurology. 2018 Oct 9;91(15):e1390-e1401. doi: 10.1212/WNL.0000000000006318. Epub 2018 Sep 12.
- Capillary cerebral amyloid angiopathy in Alzheimer’s disease: association with allocortical/hippocampal microinfarcts and cognitive decline.
Hecht M, Krämer LM, von Arnim CAF, Otto M, Thal DR.
Acta Neuropathol. 2018 May;135(5):681-694. doi: 10.1007/s00401-018-1834-y. Epub 2018 Mar 24.
- Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis.
Henstridge CM, Sideris DI, Carroll E, Rotariu S, Salomonsson S, Tzioras M, McKenzie CA, Smith C, von Arnim CAF, Ludolph AC, Lulé D, Leighton D, Warner J, Cleary E, Newton J, Swingler R, Chandran S, Gillingwater TH, Abrahams S, Spires-Jones TL. Acta Neuropathol. 2018 Feb;135(2):213-226. doi: 10.1007/s00401-017-1797-4. Epub 2017 Dec 22.
- Jigsaw Puzzling Taps Multiple Cognitive Abilities and Is a Potential Protective Factor for Cognitive Aging.
Fissler P, Küster OC, Laptinskaya D, Loy LS, von Arnim CAF, Kolassa IT.
Front Aging Neurosci. 2018 Oct 1;10:299. doi: 10.3389/fnagi.2018.00299. eCollection 2018.
- Targeting the association between telomere length and immuno-cellular bioenergetics in female patients with Major Depressive Disorder.
Boeck C, Salinas-Manrique J, Calzia E, Radermacher P, von Arnim CAF, Dietrich DE, Kolassa IT, Karabatsiakis A.
Sci Rep. 2018 Jun 20;8(1):9419. doi: 10.1038/s41598-018-26867-7.
- sAPPβ and sAPPα increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Ca2+ homeostasis and CREB1-signaling.
Hesse R, von Einem B, Wagner F, Bott P, Schwanzar D, Jackson RJ, Föhr KJ, Lausser L, Kroker KS, Proepper C, Walther P, Kestler HA, Spires-Jones TL, Boeckers T, Rosenbrock H, von Arnim CAF.
Exp Neurol. 2018 Jun;304:1-13. doi: 10.1016/j.expneurol.2018.02.010. Epub 2018 Feb 18.
- Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression.
Steinacker P, Verde F, Fang L, Feneberg E, Oeckl P, Roeber S, Anderl-Straub S, Danek A, Diehl-Schmid J, Fassbender K, Fliessbach K, Foerstl H, Giese A, Jahn H, Kassubek J, Kornhuber J, Landwehrmeyer GB, Lauer M, Pinkhardt EH, Prudlo J, Rosenbohm A, Schneider A, Schroeter ML, Tumani H, von Arnim CAF, Weishaupt J, Weydt P, Ludolph AC, Yilmazer Hanke D, Otto M; FTLDc study group.
J Neurol Neurosurg Psychiatry. 2018 Mar;89(3):239-247. doi: 10.1136/jnnp-2017-317138. Epub 2017 Nov 15.
- Auditory Memory Decay as Reflected by a New Mismatch Negativity Score Is Associated with Episodic Memory in Older Adults at Risk of Dementia.
Laptinskaya D, Thurm F, Küster OC, Fissler P, Schlee W, Kolassa S, von Arnim CAF, Kolassa IT.
Front Aging Neurosci. 2018 Feb 2;10:5. doi: 10.3389/fnagi.2018.00005. eCollection 2018.
- Mitochondrial matrix pH as a decisive factor in neurometabolic imaging.
Schaefer PM, Hilpert D, Niederschweiberer M, Neuhauser L, Kalinina S, Calzia E, Rueck A, von Einem B, von Arnim CAF.
Neurophotonics. 2017 Oct;4(4):045004. doi: 10.1117/1.NPh.4.4.045004. Epub 2017 Nov 14.
- Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress.
Menges S, Minakaki G, Schaefer PM, Meixner H, Prots I, Schlötzer-Schrehardt U, Friedland K, Winner B, Outeiro TF, Winklhofer KF, von Arnim CA, Xiang W, Winkler J, Klucken
J. Sci Rep. 2017 Feb 22;7:42942. doi: 10.1038/srep42942. PMID: 28224980 Free PMC article.
- Neurofilament as a blood marker for diagnosis and monitoring of primary progressive aphasias.
Steinacker P, Semler E, Anderl-Straub S, Diehl-Schmid J, Schroeter ML, Uttner I, Foerstl H, Landwehrmeyer B, von Arnim CA, Kassubek J, Oeckl P, Huppertz HJ, Fassbender K, Fliessbach K, Prudlo J, Roßmeier C, Kornhuber J, Schneider A, Volk AE, Lauer M, Danek A, Ludolph AC, Otto M; FTLDc Study Group.
Neurology. 2017 Mar 7;88(10):961-969. doi: 10.1212/WNL.0000000000003688. Epub 2017 Feb 8.
- The Golgi-localized, gamma ear-containing, ARF-binding (GGA) protein family alters alpha synuclein (α-syn) oligomerization and secretion.
von Einem B, Eschbach J, Kiechle M, Wahler A, Thal DR, McLean PJ, Weishaupt JH, Ludolph AC, von Arnim CAF, Danzer KM.
Aging (Albany NY). 2017 Jul 15;9(7):1677-1697. doi: 10.18632/aging.101261.
- Reduced cGMP levels in CSF of AD patients correlate with severity of dementia and current depression.
Hesse R, Lausser L, Gummert P, Schmid F, Wahler A, Schnack C, Kroker KS, Otto M, Tumani H, Kestler HA, Rosenbrock H, von Arnim CA. Alzheimers Res Ther. 2017 Mar 9;9(1):17. doi: 10.1186/s13195-017-0245-y.
- Novel Blood-Based Biomarkers of Cognition, Stress, and Physical or Cognitive Training in Older Adults at Risk of Dementia: Preliminary Evidence for a Role of BDNF, Irisin, and the Kynurenine Pathway.
Küster OC, Laptinskaya D, Fissler P, Schnack C, Zügel M, Nold V, Thurm F, Pleiner S, Karabatsiakis A, von Einem B, Weydt P, Liesener A, Borta A, Woll A, Hengerer B, Kolassa IT, von Arnim CAF.
J Alzheimers Dis. 2017;59(3):1097-1111. doi: 10.3233/JAD-170447.
- Jigsaw Puzzles As Cognitive Enrichment (PACE) – the effect of solving jigsaw puzzles on global visuospatial cognition in adults 50 years of age and older: study protocol for a randomized controlled trial.
Fissler P, Küster OC, Loy LS, Laptinskaya D, Rosenfelder MJ, von Arnim CAF, Kolassa IT.
Trials. 2017 Sep 6;18(1):415. doi: 10.1186/s13063-017-2151-9.
- No Evidence That Short-Term Cognitive or Physical Training Programs or Lifestyles Are Related to Changes in White Matter Integrity in Older Adults at Risk of Dementia.
Fissler P, Müller HP, Küster OC, Laptinskaya D, Thurm F, Woll A, Elbert T, Kassubek J, von Arnim CA, Kolassa IT.
Front Hum Neurosci. 2017 Mar 20;11:110. doi: 10.3389/fnhum.2017.00110. eCollection 2017.
- Cognitive change is more positively associated with an active lifestyle than with training interventions in older adults at risk of dementia: a controlled interventional clinical trial.
Küster OC, Fissler P, Laptinskaya D, Thurm F, Scharpf A, Woll A, Kolassa S, Kramer AF, Elbert T, von Arnim CA, Kolassa IT.
BMC Psychiatry. 2016 Sep 8;16(1):315. doi: 10.1186/s12888-016-1018-z.
- Cognitive Reserve in Alzheimer’s Dementia: Diagnostic Accuracy of a Testing-the-Limits Paradigm.
Küster OC, Kösel J, Spohn S, Schurig N, Tumani H, von Arnim CA, Uttner I.
J Alzheimers Dis. 2016 Mar 29;52(2):519-28. doi: 10.3233/JAD-151141.
- Neurofilaments in the diagnosis of motoneuron diseases: a prospective study on 455 patients.
Steinacker P, Feneberg E, Weishaupt J, Brettschneider J, Tumani H, Andersen PM, von Arnim CA, Böhm S, Kassubek J, Kubisch C, Lulé D, Müller HP, Muche R, Pinkhardt E, Oeckl P, Rosenbohm A, Anderl-Straub S, Volk AE, Weydt P, Ludolph AC, Otto M.
J Neurol Neurosurg Psychiatry. 2016 Jan;87(1):12-20. doi: 10.1136/jnnp-2015-311387. Epub 2015 Aug 21.
- Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study.
Leuzy A, Chiotis K, Hasselbalch SG, Rinne JO, de Mendonça A, Otto M, Lleó A, Castelo-Branco M, Santana I, Johansson J, Anderl-Straub S, von Arnim CA, Beer A, Blesa R, Fortea J, Herukka SK, Portelius E, Pannee J, Zetterberg H, Blennow K, Nordberg A.
Brain. 2016 Sep;139(Pt 9):2540-53. doi: 10.1093/brain/aww160. Epub 2016 Jul 7.
- Decreased IL-8 levels in CSF and serum of AD patients and negative correlation of MMSE and IL-1β.
Hesse R, Wahler A, Gummert P, Kirschmer S, Otto M, Tumani H, Lewerenz J, Schnack C, von Arnim CA.
BMC Neurol. 2016 Sep 26;16(1):185. doi: 10.1186/s12883-016-0707-z.
- Metabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration.
Schaefer PM, von Einem B, Walther P, Calzia E, von Arnim CA.
PLoS One. 2016 Dec 22;11(12):e0168157. doi: 10.1371/journal.pone.0168157. eCollection 2016.
- Alpha-, Beta-, and Gamma-synuclein Quantification in Cerebrospinal Fluid by Multiple Reaction Monitoring Reveals Increased Concentrations in Alzheimer’s and Creutzfeldt-Jakob Disease but No Alteration in Synucleinopathies.
Oeckl P, Metzger F, Nagl M, von Arnim CA, Halbgebauer S, Steinacker P, Ludolph AC, Otto M.
Mol Cell Proteomics. 2016 Oct;15(10):3126-3138. doi: 10.1074/mcp.M116.059915. Epub 2016 Aug 9.
- [Vitamins and nutritional supplements in older persons: How to diagnose and when to substitute?].
Polivka D, von Arnim CA.
Internist (Berl). 2015 Nov;56(11):1318-24. doi: 10.1007/s00108-015-3778-9.
- Serum microRNAs in sporadic amyotrophic lateral sclerosis.
Freischmidt A, Müller K, Zondler L, Weydt P, Mayer B, von Arnim CA, Hübers A, Dorst J, Otto M, Holzmann K, Ludolph AC, Danzer KM, Weishaupt JH.
Neurobiol Aging. 2015 Sep;36(9):2660.e15-20. doi: 10.1016/j.neurobiolaging.2015.06.003. Epub 2015 Jun 9.
- Frontotemporal lobar degeneration FTLD-tau: preclinical lesions, vascular, and Alzheimer-related co-pathologies.
Thal DR, von Arnim CA, Griffin WS, Mrak RE, Walker L, Attems J, Arzberger T.
J Neural Transm (Vienna). 2015 Jul;122(7):1007-18. doi: 10.1007/s00702-014-1360-6. Epub 2015 Jan 4.
- Serum Vitamin D Concentrations and Cognitive Function in a Population-Based Study among Older Adults in South Germany.
Nagel G, Herbolsheimer F, Riepe M, Nikolaus T, Denkinger MD, Peter R, Weinmayr G, Rothenbacher D, Koenig W, Ludolph AC, von Arnim CA; ActiFE Study group.
J Alzheimers Dis. 2015;45(4):1119-26. doi: 10.3233/JAD-143219.
- Tolerability and safety of Souvenaid in patients with mild Alzheimer’s disease: results of multi-center, 24-week, open-label extension study.
Olde Rikkert MG, Verhey FR, Blesa R, von Arnim CA, Bongers A, Harrison J, Sijben J, Scarpini E, Vandewoude MF, Vellas B, Witkamp R, Kamphuis PJ, Scheltens P.
J Alzheimers Dis. 2015;44(2):471-80. doi: 10.3233/JAD-141305.
- The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1).
von Einem B, Wahler A, Schips T, Serrano-Pozo A, Proepper C, Boeckers TM, Rueck A, Wirth T, Hyman BT, Danzer KM, Thal DR, von Arnim CA.
PLoS One. 2015 Jun 8;10(6):e0129047. doi: 10.1371/journal.pone.0129047. eCollection 2015.
- The role of TREM2 R47H as a risk factor for Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson’s disease.
Lill CM, Rengmark A, Pihlstrøm L, Fogh I, Shatunov A, Sleiman PM, Wang LS, Liu T, Lassen CF, Meissner E, Alexopoulos P, Calvo A, Chio A, Dizdar N, Faltraco F, Forsgren L, Kirchheiner J, Kurz A, Larsen JP, Liebsch M, Linder J, Morrison KE, Nissbrandt H, Otto M, Pahnke J, Partch A, Restagno G, Rujescu D, Schnack C, Shaw CE, Shaw PJ, Tumani H, Tysnes OB, Valladares O, Silani V, van den Berg LH, van Rheenen W, Veldink JH, Lindenberger U, Steinhagen-Thiessen E; SLAGEN Consortium, Teipel S, Perneczky R, Hakonarson H, Hampel H, von Arnim CAF, Olsen JH, Van Deerlin VM, Al-Chalabi A, Toft M, Ritz B, Bertram L.
Alzheimers Dement. 2015 Dec;11(12):1407-1416. doi: 10.1016/j.jalz.2014.12.009. Epub 2015 Apr 30.
- Serum microRNAs in patients with genetic amyotrophic lateral sclerosis and pre-manifest mutation carriers.
Freischmidt A, Müller K, Zondler L, Weydt P, Volk AE, Božič AL, Walter M, Bonin M, Mayer B, von Arnim CA, Otto M, Dieterich C, Holzmann K, Andersen PM, Ludolph AC, Danzer KM, Weishaupt JH.
Brain. 2014 Nov;137(Pt 11):2938-50. doi: 10.1093/brain/awu249. Epub 2014 Sep 5.
- Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer’s disease.
Rijal Upadhaya A, Kosterin I, Kumar S, von Arnim CA, Yamaguchi H, Fändrich M, Walter J, Thal DR.
Brain. 2014 Mar;137(Pt 3):887-903. doi: 10.1093/brain/awt362. Epub 2014 Feb 10.
- Intact protein analysis of ubiquitin in cerebrospinal fluid by multiple reaction monitoring reveals differences in Alzheimer’s disease and frontotemporal lobar degeneration.
Oeckl P, Steinacker P, von Arnim CA, Straub S, Nagl M, Feneberg E, Weishaupt JH, Ludolph AC, Otto M.
J Proteome Res. 2014 Nov 7;13(11):4518-25. doi: 10.1021/pr5006058. Epub 2014 Aug 13.
- Globular and protofibrillar aβ aggregates impair neurotransmission by different mechanisms.
Moreth J, Kroker KS, Schwanzar D, Schnack C, von Arnim CA, Hengerer B, Rosenbrock H, Kussmaul L.
Biochemistry. 2013 Feb 26;52(8):1466-76. doi: 10.1021/bi3016444. Epub 2013 Feb 14.
- [Short and simple is not always better: limitations of cognitive screening tests].
Uttner I, Wittig S, von Arnim CA, Jäger M.
Fortschr Neurol Psychiatr. 2013 Apr;81(4):188-94. doi: 10.1055/s-0032-1330333. Epub 2013 Apr 15.
- Increased levels of antigen-bound β-amyloid autoantibodies in serum and cerebrospinal fluid of Alzheimer’s disease patients.
Maftei M, Thurm F, Schnack C, Tumani H, Otto M, Elbert T, Kolassa IT, Przybylski M, Manea M, von Arnim CA.
PLoS One. 2013 Jul 18;8(7):e68996. doi: 10.1371/journal.pone.0068996. Print 2013.
- Micronutrients supplementation and nutritional status in cognitively impaired elderly persons: a two-month open label pilot study.
von Arnim CA, Dismar S, Ott-Renzer CS, Noeth N, Ludolph AC, Biesalski HK.
Nutr J. 2013 Nov 15;12(1):148. doi: 10.1186/1475-2891-12-148.
- Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1).
Wahler A, Beyer AS, Keller IE, Schnack C, von Einem B, Pröpper C, Boeckers TM, Peltan ID, Strickland DK, Hyman BT, von Arnim CA. Biochem J. 2013 Mar 1;450(2):333-43. doi: 10.1042/BJ20121100.
- Walking on sunshine: effect of weather conditions on physical activity in older people.
Klenk J, Büchele G, Rapp K, Franke S, Peter R; ActiFE Study Group.
J Epidemiol Community Health. 2012 May;66(5):474-6. doi: 10.1136/jech.2010.128090. Epub 2011 Feb 15.
- Antigen-bound and free β-amyloid autoantibodies in serum of healthy adults.
Maftei M, Thurm F, Leirer VM, von Arnim CA, Elbert T, Przybylski M, Kolassa IT, Manea M.
PLoS One. 2012;7(9):e44516. doi: 10.1371/journal.pone.0044516. Epub 2012 Sep 4.
- Genetic variants in PSEN2 and correlation to CSF β-amyloid42 levels in AD.
Lebedeva E, Stingl JC, Thal DR, Ghebremedhin E, Strauss J, Özer E, Bertram L, von Einem B, Tumani H, Otto M, Riepe MW, Högel J, Ludolph AC, von Arnim CA.
Neurobiol Aging. 2012 Jan;33(1):201.e9-18. doi: 10.1016/j.neurobiolaging.2010.07.017. Epub 2010 Sep 18.
- Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease.
Watabe-Rudolph M, Song Z, Lausser L, Schnack C, Begus-Nahrmann Y, Scheithauer MO, Rettinger G, Otto M, Tumani H, Thal DR, Attems J, Jellinger KA, Kestler HA, von Arnim CA, Rudolph KL.
Neurology. 2012 Feb 21;78(8):569-77. doi: 10.1212/WNL.0b013e318247caa1. Epub 2012 Feb 8.
- Differential sialylation of serpin A1 in the early diagnosis of Parkinson’s disease dementia.
Jesse S, Lehnert S, Jahn O, Parnetti L, Soininen H, Herukka SK, Steinacker P, Tawfik S, Tumani H, von Arnim CA, Neumann M, Kretzschmar HA, Kulaksiz H, Lenter M, Wiltfang J, Ferger B, Hengerer B, Otto M.
PLoS One. 2012;7(11):e48783. doi: 10.1371/journal.pone.0048783. Epub 2012 Nov 8.
- Efficacy of Souvenaid in mild Alzheimer’s disease: results from a randomized, controlled trial.
Scheltens P, Twisk JW, Blesa R, Scarpini E, von Arnim CA, Bongers A, Harrison J, Swinkels SH, Stam CJ, de Waal H, Wurtman RJ, Wieggers RL, Vellas B, Kamphuis PJ.
J Alzheimers Dis. 2012;31(1):225-36. doi: 10.3233/JAD-2012-121189.
- Dietary antioxidants and dementia in a population-based case-control study among older people in South Germany.
von Arnim CA, Herbolsheimer F, Nikolaus T, Peter R, Biesalski HK, Ludolph AC, Riepe M, Nagel G; ActiFE Ulm Study Group.
J Alzheimers Dis. 2012;31(4):717-24. doi: 10.3233/JAD-2012-120634.
- Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-β precursor protein.
Beyer AS, von Einem B, Schwanzar D, Keller IE, Hellrung A, Thal DR, Ingelsson M, Makarova A, Deng M, Chhabra ES, Pröpper C, Böckers TM, Hyman BT, von Arnim CA.
Neurobiol Aging. 2012 Apr;33(4):732-43. doi: 10.1016/j.neurobiolaging.2010.06.006. Epub 2010 Jul 31.
- Interaction structure of the complex between neuroprotective factor humanin and Alzheimer’s β-amyloid peptide revealed by affinity mass spectrometry and molecular modeling.
Maftei M, Tian X, Manea M, Exner TE, Schwanzar D, von Arnim CA, Przybylski M.
J Pept Sci. 2012 Jun;18(6):373-82. doi: 10.1002/psc.2404. Epub 2012 Apr 20.
- [Maintenance of health and relief for caregivers of elderly with dementia by using “initial case management”: experiences from the Lighthouse Project on Dementia, Ulm, ULTDEM-study].
Lukas A, Kilian R, Hay B, Muche R, von Arnim CA, Otto M, Riepe M, Jamour M, Denkinger MD, Nikolaus T.
Z Gerontol Geriatr. 2012 Jun;45(4):298-309. doi: 10.1007/s00391-012-0337-z.
- Summary of cerebrospinal fluid routine parameters in neurodegenerative diseases.
Jesse S, Brettschneider J, Süssmuth SD, Landwehrmeyer BG, von Arnim CA, Ludolph AC, Tumani H, Otto M.
J Neurol. 2011 Jun;258(6):1034-41. doi: 10.1007/s00415-010-5876-x. Epub 2010 Dec 25.
- Amyloid beta 1-42 in cerebrospinal fluid is associated with cognitive plasticity.
Uttner I, Schurig N, von Arnim CA, Lange-Asschenfeldt C, Brettschneider J, Riepe MW, Tumani H.
Psychiatry Res. 2011 Nov 30;190(1):132-6. doi: 10.1016/j.psychres.2011.04.017. Epub 2011 May 26.
- The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels.
Schjeide BM, Schnack C, Lambert JC, Lill CM, Kirchheiner J, Tumani H, Otto M, Tanzi RE, Lehrach H, Amouyel P, von Arnim CA, Bertram L.
Arch Gen Psychiatry. 2011 Feb;68(2):207-13. doi: 10.1001/archgenpsychiatry.2010.196.
- Spectrally resolved fluorescence lifetime imaging microscopy: Förster resonant energy transfer global analysis with a one- and two-exponential donor model.
Strat D, Dolp F, von Einem B, Steinmetz C, von Arnim CA, Rueck A.
J Biomed Opt. 2011 Feb;16(2):026002. doi: 10.1117/1.3533318.
- More than the sum of its parts? Nutrition in Alzheimer’s disease.
von Arnim CA, Gola U, Biesalski HK.
Nutrition. 2010 Jul-Aug;26(7-8):694-700. doi: 10.1016/j.nut.2009.11.009. Epub 2010 Apr 8.
- Ubiquitin as potential cerebrospinal fluid marker of Creutzfeldt-Jakob disease.
Steinacker P, Rist W, Swiatek-de-Lange M, Lehnert S, Jesse S, Pabst A, Tumani H, von Arnim CA, Mitrova E, Kretzschmar HA, Lenter M, Wiltfang J, Otto M.
Proteomics. 2010 Jan;10(1):81-9. doi: 10.1002/pmic.200900246.
- Tau-proteins as gender-specific state markers in amnestic mild cognitive impairment.
Riepe MW, Karl J, Tumani H, von Arnim CA.
Dement Geriatr Cogn Disord. 2010;30(2):93-100. doi: 10.1159/000318738. Epub 2010 Aug 18.
- An unbiased, staged, multicentre, validation strategy for Alzheimer’s disease CSF tau levels.
Petzold A, Chapman MD, Schraen S, Verwey NA, Pasquier F, Bombois S, Brettschneider J, Fox NC, von Arnim CA, Teunissen C, Pijnenburg Y, Riepe MW, Otto M, Tumani H, Scheltens P, Buee L, Rossor MN.
Exp Neurol. 2010 Jun;223(2):432-8. doi: 10.1016/j.expneurol.2009.11.010. Epub 2009 Dec 11.
- Efficient processing of Alzheimer’s disease amyloid-Beta peptides by neuroectodermally converted mesenchymal stem cells.
Habisch HJ, Schmid B, von Arnim CA, Ludolph AC, Brenner R, Storch A.
Stem Cells Dev. 2010 May;19(5):629-33. doi: 10.1089/scd.2009.0045.
- Reduced benefit from mnemonic strategies in early-stage Alzheimer’s disease: a brief testing-the-limits paradigm for clinical practice.
Uttner I, Schurig N, von Arnim CA, Lange-Asschenfeldt C, Tumani H, Riepe MW.
J Neurol. 2010 Oct;257(10):1718-26. doi: 10.1007/s00415-010-5610-8. Epub 2010 Jun 11.
- The role of low-density receptor-related protein 1 (LRP1) as a competitive substrate of the amyloid precursor protein (APP) for BACE1.
von Einem B, Schwanzar D, Rehn F, Beyer AS, Weber P, Wagner M, Schneckenburger H, von Arnim CA.
Exp Neurol. 2010 Sep;225(1):85-93. doi: 10.1016/j.expneurol.2010.05.017. Epub 2010 May 26.
- A novel presenilin1 mutation (Q223R) associated with early onset Alzheimer’s disease, dysarthria and spastic paraparesis and decreased Abeta levels in CSF.
Uttner I, Kirchheiner J, Tumani H, Mottaghy FM, Lebedeva E, Ozer E, Ludolph AC, Huber R, von Arnim CA. Eur J Neurol. 2010 Apr;17(4):631-3. doi: 10.1111/j.1468-1331.2009.02810.x. Epub 2009 Nov 12.
- Concentrations of beta-amyloid precursor protein processing products in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Steinacker P, Hendrich C, Sperfeld AD, Jesse S, Lehnert S, Pabst A, von Arnim CA, Mottaghy FM, Uttner I, Tumani H, Ludolph A, Otto M.
J Neural Transm (Vienna). 2009 Sep;116(9):1169-78. doi: 10.1007/s00702-009-0271-4. Epub 2009 Aug 1.
- Glial fibrillary acidic protein and protein S-100B: different concentration pattern of glial proteins in cerebrospinal fluid of patients with Alzheimer’s disease and Creutzfeldt-Jakob disease.
Jesse S, Steinacker P, Cepek L, von Arnim CA, Tumani H, Lehnert S, Kretzschmar HA, Baier M, Otto M.
J Alzheimers Dis. 2009;17(3):541-51. doi: 10.3233/JAD-2009-1075.
- [Polyneuropathy and monoclonal IgG/IgA gammopathy–differential neurography on the basis of two patient cases].
Abler B, Gdynia HJ, von Arnim CA.
Fortschr Neurol Psychiatr. 2009 Feb;77(2):105-9. doi: 10.1055/s-0028-1109115. Epub 2009 Feb 16.
- Visualizing interaction of proteins relevant to Alzheimer’s disease in intact cells.
Thomas AV, Berezovska O, Hyman BT, von Arnim CA.
Methods. 2008 Apr;44(4):299-303. doi: 10.1016/j.ymeth.2007.02.003.
- Impact of cholesterol level upon APP and BACE proximity and APP cleavage.
von Arnim CA, von Einem B, Weber P, Wagner M, Schwanzar D, Spoelgen R, Strauss WL, Schneckenburger H.
Biochem Biophys Res Commun. 2008 May 30;370(2):207-12. doi: 10.1016/j.bbrc.2008.03.047. Epub 2008 Mar 27.
- TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Steinacker P, Hendrich C, Sperfeld AD, Jesse S, von Arnim CA, Lehnert S, Pabst A, Uttner I, Tumani H, Lee VM, Trojanowski JQ, Kretzschmar HA, Ludolph A, Neumann M, Otto M.
Arch Neurol. 2008 Nov;65(11):1481-7. doi: 10.1001/archneur.65.11.1481.
- Radiosynthesis and evaluation of [11C]BTA-1 and [11C]3′-Me-BTA-1 as potential radiotracers for in vivo imaging of beta-amyloid plaques.
Neumaier B, Deisenhofer S, Fürst D, von Arnim CA, Thees S, Buck AK, Glatting G, Landwehrmeyer GB, Krause BJ, Müller HD, Sommer C, Reske SN, Mottaghy FM.
Nuklearmedizin. 2007;46(6):271-80.
- Radiation dosimetry and biodistribution of the beta-amyloid plaque imaging tracer 11C-BTA-1 in humans.
Thees S, Neumaier B, Glatting G, Deisenhofer S, von Arnim CA, Reske SN, Mottaghy FM.
Nuklearmedizin. 2007;46(5):175-80.
- Mechanisms of hypoxic tolerance in presymptomatic APP23 transgenic mice.
von Arnim CA, Verstege E, Etrich SM, Riepe MW.
Mech Ageing Dev. 2006 Feb;127(2):109-14. doi: 10.1016/j.mad.2005.09.025. Epub 2005 Nov 7.
- Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration.
Cao C, Lawrence DA, Li Y, Von Arnim CA, Herz J, Su EJ, Makarova A, Hyman BT, Strickland DK, Zhang L.
EMBO J. 2006 May 3;25(9):1860-70. doi: 10.1038/sj.emboj.7601082. Epub 2006 Apr 6.
- GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing.
von Arnim CA, Spoelgen R, Peltan ID, Deng M, Courchesne S, Koker M, Matsui T, Kowa H, Lichtenthaler SF, Irizarry MC, Hyman BT.
J Neurosci. 2006 Sep 27;26(39):9913-22. doi: 10.1523/JNEUROSCI.2290-06.2006.
- Fluorescence lifetime imaging microscopy (FLIM) detects stimulus-dependent phosphorylation of the low density lipoprotein receptor-related protein (LRP) in primary neurons.
Peltan ID, Thomas AV, Mikhailenko I, Strickland DK, Hyman BT, von Arnim CA.
Biochem Biophys Res Commun. 2006 Oct 13;349(1):24-30. doi: 10.1016/j.bbrc.2006.07.212. Epub 2006 Aug 14.
- Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.
Spoelgen R, von Arnim CA, Thomas AV, Peltan ID, Koker M, Deng A, Irizarry MC, Andersen OM, Willnow TE, Hyman BT.
J Neurosci. 2006 Jan 11;26(2):418-28. doi: 10.1523/JNEUROSCI.3882-05.2006.
- BACE is degraded via the lysosomal pathway.
Koh YH, von Arnim CA, Hyman BT, Tanzi RE, Tesco G.
J Biol Chem. 2005 Sep 16;280(37):32499-504. doi: 10.1074/jbc.M506199200. Epub 2005 Jul 20.
- Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, von Arnim CA, Breiderhoff T, Jansen P, Wu X, Bales KR, Cappai R, Masters CL, Gliemann J, Mufson EJ, Hyman BT, Paul SM, Nykjaer A, Willnow TE.
Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13461-6. doi: 10.1073/pnas.0503689102. Epub 2005 Sep 7.
- The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.
von Arnim CA, Kinoshita A, Peltan ID, Tangredi MM, Herl L, Lee BM, Spoelgen R, Hshieh TT, Ranganathan S, Battey FD, Liu CX, Bacskai BJ, Sever S, Irizarry MC, Strickland DK, Hyman BT.
J Biol Chem. 2005 May 6;280(18):17777-85. doi: 10.1074/jbc.M414248200. Epub 2005 Mar 4.
- Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase.
Lleó A, Waldron E, von Arnim CA, Herl L, Tangredi MM, Peltan ID, Strickland DK, Koo EH, Hyman BT, Pietrzik CU, Berezovska O.
J Biol Chem. 2005 Jul 22;280(29):27303-9. doi: 10.1074/jbc.M413969200. Epub 2005 May 25.
- Regional selectivity of amyloid mRNA expression and neurotrophins on repetitive inhibition of oxidative phosphorylation.
von Arnim CA, Hellweg R, Büchner M, Huber R, Riepe MW.
J Neural Transm (Vienna). 2005 Apr;112(4):491-8. doi: 10.1007/s00702-005-0277-5. Epub 2005 Feb 15.
- Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein.
Irizarry MC, Deng A, Lleo A, Berezovska O, Von Arnim CA, Martin-Rehrmann M, Manelli A, LaDu MJ, Hyman BT, Rebeck GW.
J Neurochem. 2004 Sep;90(5):1132-43. doi: 10.1111/j.1471-4159.2004.02581.x.
- Strain dependence of receptor regulation on chemical preconditioning in mice hippocampus.
von Arnim CA, Verstege E, Riepe MW.
Neurosci Lett. 2004 Jul 29;365(3):171-5. doi: 10.1016/j.neulet.2004.04.081.
- Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy.
von Arnim CA, Tangredi MM, Peltan ID, Lee BM, Irizarry MC, Kinoshita A, Hyman BT.
J Cell Sci. 2004 Oct 15;117(Pt 22):5437-45. doi: 10.1242/jcs.01422. Epub 2004 Oct 5.
- Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules.
Ranganathan S, Liu CX, Migliorini MM, Von Arnim CA, Peltan ID, Mikhailenko I, Hyman BT, Strickland DK.
J Biol Chem. 2004 Sep 24;279(39):40536-44. doi: 10.1074/jbc.M407592200. Epub 2004 Jul 22.
Neuroprotection and neuronal dysfunction upon repetitive inhibition of oxidative phosphorylation.
Hellweg R, von Arnim CA, Büchner M, Huber R, Riepe MW.
Exp Neurol. 2003 Oct;183(2):346-54. doi: 10.1016/s0014-4886(03)00127-4.
- Gender-dependent hypoxic tolerance mediated via gender-specific mechanisms.
von Arnim CA, Etrich SM, Timmler M, Riepe MW.
J Neurosci Res. 2002 Apr 1;68(1):84-8. doi: 10.1002/jnr.10195.
